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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
VPS13C
All Species:
10.3
Human Site:
S1566
Identified Species:
28.33
UniProt:
Q709C8
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q709C8
NP_001018098.1
3753
422390
S1566
P
F
S
E
P
S
S
S
E
K
E
S
E
L
K
Chimpanzee
Pan troglodytes
XP_510458
3836
431033
S1649
P
F
S
E
P
S
S
S
E
K
E
S
E
L
K
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_851912
3629
408076
L1566
P
S
S
E
P
S
S
L
E
K
E
S
S
E
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8BX70
3748
420070
S1564
P
S
S
D
S
S
S
S
E
K
E
P
E
L
K
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511058
3801
426177
L1603
P
S
P
G
L
S
S
L
E
Q
G
S
E
L
K
Chicken
Gallus gallus
XP_001233000
3758
422392
T1563
P
S
G
A
L
P
S
T
D
K
A
P
E
N
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001922767
3699
412330
P1555
S
T
S
S
L
P
S
P
E
R
E
S
K
K
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001192977
2470
271032
K466
I
A
M
D
I
V
V
K
A
P
V
I
V
I
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q07878
3144
357831
L1139
I
Q
M
K
G
Q
E
L
V
E
L
S
Y
E
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96.9
N.A.
87
N.A.
86.4
N.A.
N.A.
77.2
68.7
N.A.
59.6
N.A.
N.A.
N.A.
N.A.
24.1
Protein Similarity:
100
97.4
N.A.
92
N.A.
93.3
N.A.
N.A.
87.6
82.9
N.A.
76.8
N.A.
N.A.
N.A.
N.A.
41
P-Site Identity:
100
100
N.A.
66.6
N.A.
73.3
N.A.
N.A.
53.3
33.3
N.A.
33.3
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
100
N.A.
66.6
N.A.
80
N.A.
N.A.
60
46.6
N.A.
46.6
N.A.
N.A.
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
39.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
12
0
12
0
0
0
0
12
0
12
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
23
0
0
0
0
12
0
0
0
0
0
0
% D
% Glu:
0
0
0
34
0
0
12
0
67
12
56
0
56
23
0
% E
% Phe:
0
23
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
12
12
12
0
0
0
0
0
12
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
23
0
0
0
12
0
0
0
0
0
0
12
0
12
12
% I
% Lys:
0
0
0
12
0
0
0
12
0
56
0
0
12
12
56
% K
% Leu:
0
0
0
0
34
0
0
34
0
0
12
0
0
45
12
% L
% Met:
0
0
23
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
12
0
% N
% Pro:
67
0
12
0
34
23
0
12
0
12
0
23
0
0
12
% P
% Gln:
0
12
0
0
0
12
0
0
0
12
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
12
0
0
0
0
0
% R
% Ser:
12
45
56
12
12
56
78
34
0
0
0
67
12
0
12
% S
% Thr:
0
12
0
0
0
0
0
12
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
12
12
0
12
0
12
0
12
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
12
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _